CBR3 Antibody

Datasheet

Code	CSB-PA004587ESR1HU
Size	US$166
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Image	Western blot All lanes: Carbonyl reductase [NADPH] 3 antibody at 10μg/ml Lane 1: Hela whole cell lysate Lane 2: K562 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 31 kDa Observed band size: 31 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA004587ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004587ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA004587ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CBR3 Polyclonal antibody

Uniprot No.

O75828

Target Names

CBR3

Alternative Names

Carbonyl reductase (NADPH) 3 antibody; Carbonyl reductase (NADPH) 3 EC 1.1.1.184 antibody; Carbonyl reductase [NADPH] 3 antibody; Carbonyl reductase 3 antibody; CBR 3 antibody; CBR3 antibody; CBR3_HUMAN antibody; EC 1.1.1.184 antibody; Epididymis secretory protein Li 25 antibody; hCBR3 antibody; HEL S 25 antibody; NADPH dependent carbonyl reductase 3 antibody; NADPH-dependent carbonyl reductase 3 antibody; SDR21C2 antibody; Short chain dehydrogenase/reductase family 21C member 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Carbonyl reductase [NADPH] 3 protein (118-277AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).

Gene References into Functions

CBR3 730G>A is significantly associated with recurrence- free survival in patients who received intravesical chemotherapy with pirarubicin after complete transurethral resection. PMID: 30125887
No significant correlation between cardiotoxicity and SNPs within the CBR pathway. Further investigation into CBR SNPs in a larger adult sample is needed. PMID: 26563179
association of SNPs in ABCB1 and CBR3 with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines. PMID: 26799497
Variants of CBR3 and GSTP1 enzymes may be associated with changes in short-term functional cardiac parameters. PMID: 23182048
genetic polymorphism in the CBR3 gene conferred risk of type 2 diabetes and insulin resistance in Chinese. The association was probably mediated through modulation of adipogenesis. PMID: 22527884
CBR3 polymorphisms contribute to increased cardiomyopathy risk associated with anthracycline treatment of childhood cancer. PMID: 22124095
CBR3 is a novel target gene of inflammatory stimuli; elucidation of its detailed role in inflammation deserves further investigation. PMID: 22425771
Computational searches identify a conserved antioxidant response element(ARE) in the distal carbonyl reductase 3 (CBR3) promoter region. PMID: 22001310
The CBR3 distal promoter contains an activating cis-regulatory element that is responsive to Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
CBR3 is regulated via NRF2-dependent signaling pathways, a finding and plays an important role in the cellular response to oxidative stress. PMID: 20806931
analysis of the structural basis for substrate specificity in human monomeric carbonyl reductases CBR3 PMID: 19841672
The common carbonyl reductase 3 (CBR3)valine244methionine polymorphism encodes for CBR3 isoforms with distinctive enzymatic properties, as revealed in DNA variation panels from 10 ethnic groups. PMID: 15537833
There was a trend toward an association between the CBR3 V244M polymorphism and the risk of CHf PMID: 18457324
Polymorphisms in CBR3 may explain interindividual and interethnic variability of doxorubicin pharmacokinetics and pharmacodynamics. PMID: 18551042
CBR3 polymorphisms have no significant influence on the pharmacokinetics of doxorubicin in Asian breast cancer patients. PMID: 19016765
identified the promoter of human CBR3. Liver samples from black donors showed higher relative CBR3 mRNA levels than samples from whites PMID: 19590938
carbonyl reductase has an important function in modifying the metastatic behavior of malignant tumors. PMID: 10728668
Decreased Carbonyl Reductase expression in epithelial ovarian cancer is associated with RLN metastasis and poor survival PMID: 11592776

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Subcellular Location

Cytoplasm.

Protein Families

Short-chain dehydrogenases/reductases (SDR) family

Tissue Specificity

Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.

Database Links

HGNC: 1549

OMIM: 603608

KEGG: hsa:874

STRING: 9606.ENSP00000290354

UniGene: Hs.154510

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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